Association of Interictal Epileptiform Discharges with Sleep and Anti-Epileptic Drugs

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Association of Interictal Epileptiform Discharges with Sleep and Anti-Epileptic Drugs.

BACKGROUND The presence of interictal epileptiform discharges (IEDs) in electroencephalogram (EEG) is diagnostic of epilepsy. Latent IEDs are activated during sleep. Anti-epileptic drugs (AEDs) improve sleep. AEDs, sleep, and IEDs may interact and affect epilepsy management. PURPOSE To explore the occurrence of IEDs and its association with sleep and AED status in suspected patients of epilep...

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Interictal Epileptiform Discharges

EEG remains the primary technique in the diagnosis, characterization, and localization of partial seizures. This review examines the significance and character of interictal epileptiform abnormailites, periodic lateralized epileptiform discharges, and ictal patterns in patients with partial epilepsy. Interictal epileptiform discharges are common and assist in the diagnosis and localization of p...

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Interictal epileptiform discharges and phasic phenomena of REM sleep.

The objective of this study was to assess the effect of phasic rapid eye movement (REM) sleep events on interictal epileptiform discharges (IEDs). Twelve patients with focal epilepsy and IEDs during REM sleep were examined by video-EEG monitoring. The number of IEDs was calculated in different REM sleep episodes according to the rate of rapid eye movements. A negative correlation was identified...

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Interictal epileptiform discharges do not change before seizures during sleep.

PURPOSE Whether interictal epileptiform discharges (IEDs) increase, decrease, or are unchanged before epileptic seizures has implications for the pathophysiology of epilepsy. Prior studies relating IEDs and seizures have not demonstrated a change in IEDs before seizures. However, they have not controlled for changes in the depth of sleep. Our objective was to test the hypothesis that IEDs are r...

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Detection of Interictal Epileptiform Discharges in Eeg

The diagnosis of epilepsy heavily depends on the detection of epileptiform discharges in interictal EEG, the EEG in between two seizures. By visual analysis a physician wants to detect these epileptiform discharges (spikes). Due to the wide variety of morphologies of epileptiform discharges, and their similarity to waves that are part of normal EEG or to artifacts, this detection is far from st...

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ژورنال

عنوان ژورنال: Annals of Neurosciences

سال: 2016

ISSN: 0972-7531,0976-3260

DOI: 10.1159/000449483